Systemic lupus erythematosus: presence in human serum of an unusual acid-labile leukocyte interferon.

Serum alpha interferon and lymphocyte inclusions in systemic lupus erythematosus.

The relationship between serum acid-labile alpha interferon and tubuloreticular inclusions within the cytoplasm of circulating lymphocytes was studied in 46 patients with systemic lupus erythematosus. Elevated levels of interferon (greater than or equal to 8 IU/ml) were found in 17 patients and lymphocyte inclusions in 35. The mean serum interferon concentration in patients with lymphocyte incl...

Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from systemic lupus erythematosus patients with and without circulating interferon

The interferon (IFN)-induced enzyme 2-5A synthetase was elevated in mononuclear cells from both serum IFN-positive and -negative systemic lupus erythematosus (SLE) patients. This suggests that a much higher percentage of patients than previously thought produce endogenous IFN. These results may partly explain findings that mononuclear cells from SLE patients are deficient in IFN production in v...

Increased Serum Levels of Soluble B7-H4 in Patients with Systemic Lupus Erythematosus

Large Ovarian Hemorrhagic Cyst and Immune Thrombocytopenia as Early Manifestations of Systemic Lupus Erythematosus (SLE)

Hematologic abnormali"es are generally present among systemic lupus erythematosus pa"ents. Idiopathic thrombocytopenic purpura can be the first manifesta"on of SLE, followed by other symptoms and signs of disease appearing several years later. Although bleeding due to immune thrombocytopenic purpura is usually mild and occurs in mucocutaneous surfaces, but it may be severe and represent in u...

Is there any Association Between Human Lymphotropic Virus Type I (HTLV-I) Infection and Systemic Lupus Erythematosus? An Original Research and Literature Review